24/01/29
Article: How does chronic stress harm the gut? New clues emerge
Summary: Chronic stress disrupts the gut microbiome and contributes to gastrointestinal issues like IBS and IBD. Stress triggers increased levels of the bacterium Lactobacillus and its metabolite indole-3-acetate (IAA) in the gut, which impairs the function of intestinal stem cells and reduces their protective abilities. Evidence suggests these stress-induced changes may also affect humans, as elevated Lactobacillus and IAA levels were found in people with depression. Supplementing stressed mice with α-ketoglutarate improved stem cell function, though more research is needed to assess its long-term effectiveness. The study highlights a specific biochemical pathway linking stress to gut dysfunction, but further investigation is needed to fully understand this complex relationship. - 우리가 스트레스 받을때 장도 스트레스 받는다. 스트레스 condition에서 생기고 증식되는 특정 박테리아가 indone-3-acetate (IAA)라는 물질을 생성하고, 이게 스트레스 환경에서 장의 stem cell이 protector cell로써 발전하고 역할 하는것을 방해한다. |
flare-ups
Mental stress has long been linked to flare-ups of gastrointestinal conditions such as irritable bowel syndrome (IBS)
It implies a sudden worsening or exacerbation of the condition's symptoms.
예시: After weeks of managing her arthritis symptons, she experienced a sudden flare-up of pain and inflmmation in her joint, making it difficult for her to move
end up with + 명사
The aninmals ended up with reduced level of cells that help to protect the intestines from pathogens, compare with mice that weren't stressed.
In the sentence you provided, "end up with" means to result in or to find oneself with a particular outcome or situation. It implies reaching a certain state or condition after a series of events or circumstances.
예시: After hours of searching, we ended up with a only a few pices of useful information about the missing person.
kick off
Thaiss also says that the IAA study tackled only the downstream effects of stress on the gut — more work is needed to understand how the brain transmits signals that kick off the bacterial proliferation.
In the sentence you provided, "kick off" means to initiate or start something, especially in a sudden or energetic manner. It implies the beginning or activation of a process or event.
예시: The team captain's speech kicked off the championship game with a surge of energy and determination among the players.
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