24/01/23 영어공부 - 알파폴드 관련 기사

24/01/23 

Article: AlphaFold found thousands of possible psychedelics. Will its predictions help drug discovery?

https://www.nature.com/articles/d41586-024-00130-8?utm_source=Live+Audience&utm_campaign=d659e98d37-briefing-dy-20240119&utm_medium=email&utm_term=0_b27a691814-d659e98d37-51747224

 

Summary: Researchers have utilized the AI tool AlphaFold to identify hundreds of thousands of potential new psychedelic molecules for developing antidepressants. AlphaFold, developed by DeepMind, has proven to be a significant advancement in protein structure prediction, offering an alternative to the time-consuming experimental methods traditionally used in drug discovery. Although some skepticism exists regarding its accuracy compared to experimental protein structures, recent studies show AlphaFold’s predictions can effectively identify drug candidates, with similar success rates to experimental methods. However, AlphaFold's predictions often yield different drug candidates than those identified through experimental structures, suggesting that while the tool is promising, it may not completely replace experimental approaches. The continued refinement of AlphaFold and similar tools holds potential for revolutionizing drug discovery, though their role will likely complement rather than fully replace traditional methods.

 

Stand in for

But some scientists had been starting to doubt whether AlphaFold’s predictions could stand in for gold standard experimental models in the hunt for new drugs

 

the phrase "stand in for" means to serve as a substitute or replacement for something else.
대체, 대안

 

예시: After the lead actor fell ill, the understudy had to stand in for him during the performance

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Plucked from 

They ran the same screen with models of the proteins plucked from the AlphaFold database

 

the term "plucked" is used metaphorically to mean extracted or taken from.
뽑다, 추출하다

 

예시: She plucked a rose from the garden.

 

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[sentence], For which [sentence]

In unpublished work, Carlsson’s team has found that AlphaFold structures are good at identifying drugs for a sought-after class of target called G-protein-coupled receptors, for which their hit rate is around 60%.

 

Used as a relative pronoun phrase that refers back to the previously mentioned "class of target called G-protein-coupled receptors." It introduces additional information about the target class for which the AlphaFold structures are good at identifying drugs

Used when a preposition (like "for") is required or when a more formal tone is desired.

"for which" introduces a non-restrictive (non-essential) clause providing additional information

앞에 있는 단어에 대한 부가적인 설명 (꼭 필요하진 않음) 할 때, 보통 for을 필요로 하는 문장에서 사용

 

예시: The book, for which I had been searching, was finally found on the top shelf. 

The software, for which she paid a significant amount, proved to be highly efficient. 

The project, for which they had high hopes turned out to be a major success. 

 

Protein structures predicted by AlphaFold have helped to identify candidate drug compounds. Credit: DeepMind